These researchers found that the presence of high amounts of HIV in the blood seemed to cause CD8+ T cell exhaustion; when antigen was reduced, either as a result of treatment with antiretroviral drugs, or evolution of viral epitopes to avoid recognition by CD8+ T cells, these epitope-specific CD8+ T cells recovered some of their original functions. These findings suggest that CD8+ T cell exhaustion is the consequence, rather than the cause, of persistent replication of HIV.
In a related article, Sarah Rowland-Jones and Thushan de Silva (from the Medical Research Council in Gambia), who were not involved in the study, discuss approaches to treat HIV efficiently by suppressing the viral load early in infection aimed at preserving HIV-1-specific immune function. They evaluate whether such strategies are likely to be practical.
Citation: Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, et al. (2008) Antigen load and viral sequence diversification determine the functional profile of HIV-1– specific CD8þ T cells. PLoS Med 5(5):e100.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
journal.pmed.0050100
CONTACTS:
Sue McGreevey
Public Affairs Office
Massachusetts General Hospital
Boston, MA
+1 617 724-2764
smcgreevey@partners.org
Marcus Altfeld
Massachusetts General Hospital
Partners AIDS Research Center
149 13th Street
Boston, MA 02129
United States of America
+1 617-724-2461
+1 617-724-8586 (fax)
maltfeld@partners.org
Related PLoS Medicine Research in Translation:
Citation: Rowland-Jones S, de Silva T (2008) Resisting immune exhaustion in
HIV-1 infection. PLoS Med 5(5): e103.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
journal.pmed.0050103
CONTACT:
Sarah Rowland-Jones
Weatherall Institute of Molecular Medicine
MRC Human Immunology Unit
Radcliffe Hospital
Headley Way
Oxford, OX3 9DS
United Kingdom
+44 (1865) 222 316
+44 (1865) 222 502 (fax)
sarah.rowland-jones@ndm.ox.ac.uk
THE FOLLOWING ARTICLE WILL ALSO BE PUBLISHED ONLINE:
Hypofibrinolysis and other risk factors for first venous thrombosis
Frits Rosendaal and colleagues from Leiden University Medical Center
show that the combination of hypofibrinolysis with oral contraceptive use,
immobilization, or factor V Leiden results in a risk of venous thrombosis
that exceeds the sum of the individual risks.
Citation: Meltzer ME, Lisman T, Doggen CJM, de Groot PG, Rosendaal
FR (2008) Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on
the risk of a first venous thrombosis. PLoS Med 5(5): e97.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
journal.pmed.0050097
CONTACTS:
Frits R. Rosendaal
Leiden University Medical Center
Clinical Epidemiology and Hematology
PO Box 9600
Leiden, 2300 RC
Netherlands
+31 715 264 037
f.r.rosendaal@lumc.nl
Source : Public Library of Science
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