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Thursday, March 12, 2009

article : Schick Test

Schick Test: The intracutaneous skin test introduced by Schick in 1913 that enables us to distinguish between individuals who are susceptible and those who are resistant (i.e., immune) to diphtheria toxin and to test for sensitivity to toxoid. The test is based on the following empirical findings:

    1. Intracutaneous injection of 1/50 MLD (minimal lethal dose) (for a guinea pig) of diphtheria toxin produces a strong, but tolerable, reaction in individuals having no antitoxin.


    2. Individuals having 1/30 unit or more of antitoxin per ml of blood neutralize this test dose and show no reaction. Such individuals are also usually resistant to diphtheria.

REACTIONS TO SCHICK TEST

TOXIN
TOXOID
SKIN RESPONSE
36 h
120 h
36 h
120 h
INTERPRETATION
POSITIVE REACTION
-
+
-
-
Nonimmune, Nonsensitive

NEGATIVE REACTION

-
-
-
-
Immune, Nonsensitive

PSEUDO REACTION

+
-
+
-
Immune, Sensitive

COMBINED REACTION

+
+
+
-
Nonimmune, Sensitive

Designed & Maintained by David M. Rollins
Copyright © 2000, D.M. Rollins and S.W. Joseph
Revised: August 2000
URL: http://life.umd.edu

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